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1.	Locke, Adam E, et al. (author) Genetic studies of body mass index yield new insights for obesity biology. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Journal article (peer-reviewed)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
2.	Holmes, Michael V, et al. (author) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. 2014 In: BMJ: British Medical Journal. - : BMJ. - 1756-1833. ; 349:Jul 10, s. 4164-4164 Journal article (peer-reviewed)abstract To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Kuh, Diana (2); Sattar, Naveed (2); Wareham, Nicholas J. (2); Tjønneland, Anne (1); Boeing, Heiner (1); Sacerdote, Carlotta (1); show more...; Khaw, Kay-Tee (1); Franks, Paul (1); Hankey, Graeme J. (1); Maitland-Van der Zee ... (1); Berne, Christian (1); Lyssenko, Valeriya (1); Groop, Leif (1); Vandenput, Liesbeth, ... (1); März, Winfried (1); Salomaa, Veikko (1); Perola, Markus (1); Chen, Jin (1); Lind, Lars (1); Lannfelt, Lars (1); Raitakari, Olli T (1); Melander, Olle (1); LaCroix, Andrea Z. (1); Hardy, Rebecca (1); Melbye, Mads (1); Davey Smith, George (1); Haiman, Christopher ... (1); Schumacher, Fredrick ... (1); Berndt, Sonja I (1); Chanock, Stephen J (1); Grönberg, Henrik (1); Campbell, Harry (1); Rudan, Igor (1); Ohlsson, Claes, 1965 (1); Strachan, David P (1); Goodall, Alison H (1); Deloukas, Panos (1); Syvänen, Ann-Christi ... (1); Peters, Ulrike (1); Ricceri, Fulvio (1); Shungin, Dmitry (1); North, Kari E. (1); Hallmans, Göran (1); Clarke, Robert (1); Hall, Per (1); Zheng, Wei (1); Fall, Tove (1); Johansson, Åsa (1); Stancáková, Alena (1); Kuusisto, Johanna (1); show less...

University: Uppsala University (2); Lund University (2); Karolinska Institutet (2)Undo refine; University of Gothenburg (1); Umeå University (1); Högskolan Dalarna (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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